JAK2 V617F mutation analysis in different myeloid lineages (granulocytes, platelets, CFU-MK, BFU-E and CFU-GM) in essential thrombocythemia patients
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منابع مشابه
Loss of hematopoietic progenitor cells CFU-GEMM, BFU-E, CFU-Mk, and CFU-GM in the acquired immunodeficiency syndrome (AIDS)?
Hematological abnormalities have been found in the majority of patients with AIDS, in addition to immunological derangements [1]. Furthermore, treatment of opportunistic infections with folic acid antagonists and of neoplasms with cytostatic drugs is frequently complicated by profound thrombocytopenia, neutropenia, and anemia, thus resulting in the withdrawal of the drugs. In the present study ...
متن کاملEffects of Recombinant a and ‘y Interferons on the In Vitro Growth of Circulating Hematopoietic Progenitor Cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) From Patients With Myelofibrosis With Myeloid Metaplasia
Myeloflbrosis with myeloid metaplasia (MMM) is a chronic myeloproliferative disorder due to clonal expansion of a pluripotent hematopoietic progenitor cell with secondary marrow fibrosis. No definitive treatment has as yet been devised for this condition, which shows a marked variability in clinical course. To evaluate whether excessive hematopoietic progenitor cell proliferation could be contr...
متن کاملErythroid progenitors (BFU-e and CFU-e) in acute leukaemia.
Bone marrow erythroid progenitor cells were examined from 50 cases of acute leukaemia and from 20 normal subjects using an in vitro semisolid culture method. Numbers of both primitive erythroid progenitor cells (BFU-e) and later-stage erythroid progenitor cells (CFU-e) were remarkably depressed in patient with acute leukaemia in active phase. However, both BFU-e and CFU-e recovered to within no...
متن کاملDifferences in the JAK2 and MPL mutation status in the cell lineages of the bcr/abl-negative chronic myeloproliferative neoplasm subtypes.
OBJECTIVE While the somatic mutation of Janus Kinase 2 (JAK2) and the thrombopoietin receptor (c-MPL) gene are thought to affect the pathogenesis of bcr/abl negative chronic myeloproliferative neoplasm (MPN), the relationship between the mutation and the clinical features remain obscure. METHODS The mutation status of these genes in granulocytes, platelets, T-cells, and erythroid colonies (BF...
متن کاملFamilial Essential Thrombocythemia Associated with MPL W515L Mutation in Father and JAK2 V617F Mutation in Daughter
Familial essential thrombocythemia features the acquisition of somatic mutations and an evolution similar to the sporadic form of the disease. Here we report two patients-father and daughter-with essential thrombocythemia who displayed a heterogeneous pattern of somatic mutations. The JAK2 V617F mutation was found in the daughter, while the father harbored the MPL W515L mutation. This case repo...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2006
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2404341